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I agree that lack of appropriate tools like genetic animal models or well-validated antibodies for very novel targets, it really slows down and makes it very difficult to narrow down those target lists to some manageable amount. 2

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GLP-1 receptor agonists are synthetic molecules that mimic the action of endogenous GLP-1 with significantly extended half-lives, enabling sustained metabolic effects

[PubMed: 39676787] [Free PMC Article] Larsen AT, Mohamed KE, Sonne N, et al